![]() (1) Other liver cancer types include childhood hepatoblastoma, adult cholangiocarcinoma (originating from the intrahepatic biliary ducts), and angiosarcoma (from the intrahepatic blood vessels). (2) Hepatocellular carcinoma (HCC) accounts for up to 90% of primary liver cancers. ![]() Primary liver cancer is a major health problem, (1) representing the second leading cause of cancer-related deaths in the world. Keywords: ion channels, Eag1, hepatocellular carcinoma, astemizole, diethylnitrosamine ![]() Here, we will review first some general aspects of HCC including the current biomarkers and therapies, and then we will focus on Eag1 channels as promising tools in the early diagnosis of HCC. Actually, in vivo studies have shown that astemizole may have clinical utility for HCC prevention and treatment. Astemizole has gained great interest as a potential anticancer drug because it targets several proteins involved in cancer including Eag1. The channel is also overexpressed in human HCC. Eag1 is overexpressed during HCC development from the cirrhotic and the preneoplastic lesions preceding HCC in a rat model. Especially, the ether a-go-go-1 (Eag1) voltage-gated potassium channel has been suggested as an early marker for HCC. Ion channels have been proposed as potential tumor markers and therapeutic targets for several cancers including HCC. ![]() Thus, the identification of early biomarkers and novel therapies is essential to improve HCC patient survival. HCC is usually asymptomatic at potential curative stages, and it has very poor prognosis if detected later. Abstract: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. ![]()
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January 2023
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